Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling
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چکیده
منابع مشابه
Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling.
Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide synthase (eNOS and nNOS, respectively). There are increasing data indicating that NO modulates various proteins involved in excitation-contraction coupling (ECC), and here we discuss the evidence that NO may modu...
متن کاملExcitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach.
During calcium-induced calcium-release, the ryanodine receptor (RyR) opens and releases large amounts of calcium from the sarcoplasmic reticulum into the cytoplasm of the myocyte. Recent experiments have suggested that cooperativity between the four monomers comprising the RyR plays an important role in the dynamics of the overall receptor. Furthermore, this cooperativity can be affected by the...
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Although interactions between superoxide (O(2)(.-)) and nitric oxide underlie many physiologic and pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly understood. Here, we demonstrate that xanthine oxidoreductase (XOR), a prototypic superoxide O(2)(.-) -producing enzyme, and neuronal nitric oxide synthase (NOS1) coimmunoprecipitate and colocalize in the sar...
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It is well established that excitation contraction (EC) coupling in cardiac myocytes is mediated by the entry of calcium ions (Ca 2 ) from the bathing medium into the cell cytoplasm (Fabiato, 1985), which then triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum (SR). More recently, it was proposed that a second, quite separate, EC-coupling process, mediated by an eff...
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gitudinal system of the SR, governing the Ca storage compartment with the highest recruitable amount of Ca in cardiac myocytes. The RyR are chemically coupled to L-type Ca channels via Ca, and a relatively small amount of Ca entering the cell via L-type Ca channels (depending on species or stimulation rate) activates a limited number of adjacent RyRs. This leads to Ca release from the SR, and a...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1093/cvr/cvm012